Table 3.

Multivariable Multinomial Logistic Regression Model for 3, 6 and 9 years of follow-up by male and female: Tehran lipids and glucose study

	Male				Female
	Regress to normal		Progress to T2DM		Regress to normal		Progress to T2DM
	RRR (95% CI)	P-value	RRR (95% CI)	P-value	RRR (95% CI)	P-value	RRR (95% CI)	P-value
After 3 years
Model 1
Intervention	1.50 (1.10–2.04)	0.009	1.54 (1.04–2.27)	0.02	1.30 (1.00-1.69)	0.05	0.87 (0.61–1.23)	0.44
Model 2
Intervention	1.53 (1.11–2.10)	0.008	1.53 (1.02–2.31)	0.03	1.25 (0.95–1.64)	0.11	0.86 (0.60–1.24)	0.50
After 6 years
Model 1
Intervention	1.42 (0.99–2.02)	0.05	1.78 (1.19–2.65)	0.005	1.11 (0.83–1.49)	0.47	0.87 (0.62–1.22)	0.43
Model 2
Intervention	1.47 (1.02–2.12)	0.04	1.82 (1.20–2.76)	0.005	1.03 (0.75–1.40)	0.79	0.85 (0.60–1.21)	0.45
After 9 years
Model 1
Intervention	1.20 (0.76–1.88)	0.41	1.31 (0.83–2.07)	0.23	1.20 (0.76–1.88)	0.29	1.31 (0.83–2.07)	0.64
Model 2
Intervention	1.32 (0.83–2.10)	0.29	1.41 (0.88–2.26)	0.14	1.15 (0.78–1.70)	0.48	1.11 (0.75–1.65)	0.60

T2DM = Type 2 Diabetes; RRR = Relative Risk Ratio

Model 1 adjusted for age and model 2 further adjusted for all possible confounders measured at the baseline including BMI, systolic and diastolic blood pressure, FPG, 2 h-PG, HDL-C, TG, Education levels (≤ 6, 6–12 and > 12 years of education), Low physical activity (< 3 days of performing sports or heavy physical activity per week), current smoking, anti-hypertensive drug use, and Family history of T2DM