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. 2024 Nov 26;15:10232. doi: 10.1038/s41467-024-54145-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 9 — Distribution of the five pre-existing TNBC molecular subtypes into different spatial archetypes in the ST TNBC (N = 94), METABRIC (N = 335) and SCAN-B (N = 672) cohorts. The molecular subtypes were defined from the ST global pseudobulk and from METABRIC and SCAN-B bulk transcriptomes. The main characteristics of each spatial archetype are summarized, highlighting the potential for precision medicine in TNBC with specific therapeutic strategies for each spatial archetype. Source data are provided as a Source Data file. ADC antibody-drug conjugate, BL basal-like, EMT epithelial-mesenchymal transition, ICB immune checkpoint blockade, IM immunomodulatory, LAR luminal androgen receptor, M mesenchymal, MSL mesenchymal stem-like, PARPi poly-ADP ribose polymerase inhibitor, SA spatial archetype, TLS tertiary lymphoid structures.