Table 3.
Impact of daily fever burden within the study period of 16 days on outcome parameters in 347 to 375 patients
| Adjusted OR | 95% -CI | P-value | |
|---|---|---|---|
| Models: development of DCIa | |||
| Fever burden > 37.9 °C, °C × h | 1.01 | 0.97–1.06 | 0.660 |
| Fever burden > 37.0 °C, °C × h | 1.01 | 0.99–1.03 | 0.308 |
| Fever burden > 37.5 °C, °C × h | 1.01 | 0.98–1.04 | 0.448 |
| Fever burden > 38.2 °C, °C × h | 1.02 | 0.95–1.08 | 0.651 |
| Models: poor functional 3-month outcome (mRS 3–6)b | |||
| Fever burden > 37.9 °C, °C × h | 1.07 | 1.01–1.32 | 0.027 |
| Fever burden > 37.0 °C, °C × h | 1.00 | 0.98–1.02 | 0.883 |
| Fever burden > 37.5 °C, °C × h | 1.03 | 0.99–1.06 | 0.155 |
| Fever burden > 38.2 °C, °C × h | 1.12 | 1.01–1.24 | 0.037 |
| Maximum temperature per day, °C | 0.919 | 0.724–1.17 | 0.489 |
| Maximum temperature per day > 37.9 °C | 1.04 | 0.73–1.47 | 0.851 |
| Models: functional worse 3-month outcome, ordinalb | |||
| Fever burden > 37.9 °C, °C × h | 1.08 | 1.03–1.13 | < 0.001 |
| Fever burden > 37.0 °C, °C × h | 1.01 | 0.99–1.03 | 0.299 |
| Fever burden > 37.5 °C, °C × h | 1.03 | 1.01–1.06 | 0.012 |
| Fever burden > 38.2 °C, °C × h | 1.13 | 1.05–1.21 | 0.001 |
| Maximum temperature per day, °C | 0.96 | 0.80–1.16 | 0.691 |
| Maximum temperature per day > 37.9 °C | 1.11 | 0.86–1.43 | 0.422 |
| Models: poor functional 12-month outcome (mRS 3–6)c | |||
| Fever burden > 37.9 °C, °C × h | 1.07 | 1.01–1.13 | 0.020 |
| Fever burden > 37.0 °C, °C × h | 0.99 | 0.97–1.02 | 0.494 |
| Fever burden > 37.5 °C, °C × h | 1.02 | 0.99–1.06 | 0.229 |
| Fever burden > 38.2 °C, °C × h | 1.12 | 1.02–1.24 | 0.018 |
| Models: hospital mortalitya | |||
| Fever burden > 37.9 °C, °C × h | 1.07 | 1.00–1.14 | 0.045 |
| Fever burden > 37.0 °C, °C × h | 0.997 | 0.97–1.03 | 0.865 |
| Fever burden > 37.5 °C, °C × h | 1.03 | 0.98–1.07 | 0.246 |
| Fever burden > 38.2 °C, °C × h | 1.11 | 1.01–1.21 | 0.037 |
| Models: ICU length of stay, daysa | |||
| Fever burden > 37.9 °C, °C × h | 1.09 | 0.81–1.47 | 0.573 |
| Fever burden > 37.0 °C, °C × h | 1.03 | 0.91–1.16 | 0.665 |
| Fever burden > 37.5 °C, °C × h | 1.04 | 0.87–1.25 | 0.647 |
| Fever burden > 38.2 °C, °C × h | 1.12 | 0.72–1.76 | 0.615 |
Multivariable logistic regression analysis was done with a generalized estimating equation model with an independent correlation matrix to account for repeated measures; the dependent variable was used as binary (development of DCI, dichotomized 3-month and 12-month outcome, hospital mortality), ordinal (3-month mRS) or linear (ICU days) variable. For each fever cutoff (i.e., > 37.9 °C, > 37.0°C, > 37.5 °C, > 38.2 °C) separate models were calculated. All models were corrected for Hunt & Hess score on admission, age, daily doses of paracetamol, metamizole, naproxen, diclofenac, pethidine, daily usage of surface/intravascular cooling, pneumonia, ventriculitis, sepsis/bacteremia, urinary tract infection, and DCI (except for the DCI model)
CI confidence interval, DCI delayed cerebral ischemia, ICU intensive care unit, mRS modified Rankin Scale, OR, odds ratio
a375 patients
b14 patients were lost to 3-month follow-up, resulting in 361 included patients
c28 patients were lost to 12-month follow-up, resulting in 347 included patients