Figure 7.

Plausible parameter domains indicate distinguishing recruitment rates for membrane HOPS and Sec17. Two-dimensional histograms depicting parameter values that satisfice all simulation criteria. (A) HOPS and Sec17 turnover rate constants (K₁ and K₇, respectively). (B) HOPS and Sec17 recruitment rate constants (K₁ and K₆, respectively). (C) Rate constants for Sec17 recruitment and turnover (K₆ and K₇, respectively). Plots represent combined parameter sets from two ABC trials, giving a total of N = 10⁴ parameter sets satisficing all simulation criteria (see Table 2).