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. 2024 Nov 26;14(1):205. doi: 10.1038/s41408-024-01163-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Low-power images (left column) of biopsied lymph nodes show varying degrees of architectural effacement by a paracortical infiltrate. High-power images (2^nd to left column) of the paracortical infiltrate show atypical mature lymphocytes. T-cell-specific immunohistochemical stains (Case 1, BetaF1; Case 2, CD2; Cases 3 and 4, CD3) highlight the T-cell atypia. Follicular dendritic cell meshworks (fDCs) are focally mildly expanded in all cases (CD21 immunostain). T follicular helper cell (Tfh) antigens were expressed in all cases, illustrated by ICOS (Cases 1-3) and PD1 (Case 4) immunostains.