Table 7.
Association between the14-bp I/D polymorphism and cancers: Subgroup analysis according to cancer grades.
| Genetic models | Grades | Effect size and 95 % interval |
Heterogeneity |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | OR | Lower limit | Upper limit | P-value | I2 | P-het | τ2 | P-Begg | P-Egger | ||
| D vs. I | High grade | 4 | 1,288 | 0,992 | 1,672 | 0,057 | 19,13 | 0,295 | 0,014 | NS | NS |
| Low grade | 5 | 1,354 | 1,148 | 1,597 | 0,000 | 0,00 | 0,604 | 0,000 | NS | NS | |
| DD vs. DI + II | High grade | 4 | 1,529 | 1,079 | 2,166 | 0,017 | 0,00 | 0,484 | 0,000 | NS | NS |
| Low grade | 5 | 1,451 | 1,111 | 1,896 | 0,006 | 3,52 | 0,387 | 0,004 | NS | NS | |
| DD + DI vs. II | High grade | 4 | 1,246 | 0,724 | 2,144 | 0,428 | 38,02 | 0,184 | 0,117 | NS | NS |
| Low grade | 5 | 1,496 | 1,142 | 1,960 | 0,003 | 0,00 | 0,992 | 0,000 | NS | NS | |
| DD + II vs. DI | High grade | 4 | 1,121 | 0,746 | 1,685 | 0,581 | 31,65 | 0,222 | 0,055 | NS | NS |
| Low grade | 5 | 0,978 | 0,774 | 1,235 | 0,850 | 0,00 | 0,623 | 0,000 | NS | NS | |
| DI vs. II | High grade | 4 | 1,121 | 0,624 | 2,012 | 0,702 | 39,75 | 0,173 | 0,141 | NS | NS |
| Low grade | 5 | 1,350 | 1,009 | 1,804 | 0,043 | 0,00 | 0,984 | 0,000 | NS | NS | |
| DD vs. II | High grade | 4 | 1,573 | 0,908 | 2,724 | 0,106 | 22,46 | 0,276 | 0,074 | NS | NS |
| Low grade | 5 | 1,768 | 1,281 | 2,440 | 0,001 | 0,00 | 0,781 | 0,000 | NS | NS | |
| DD vs. DI | High grade | 4 | 1,449 | 0,999 | 2,102 | 0,051 | 0,00 | 0,440 | 0,000 | NS | NS |
| Low grade | 5 | 1,296 | 0,973 | 1,726 | 0,076 | 3,14 | 0,389 | 0,004 | NS | NS | |
Bold: significant P-value (<0,05); N: number of studies; NS: Not Significant; OR: odds ratio; I2 : heterogeneity test; τ2 , tau-squared; I/D : insertion/deletion; P- het, p-heterogeneity ; bp: base pairs. Low grade includes Grades I + II. Low grade includes Grades III + IV.