. 2024 Oct 23;10(22):e39740. doi: 10.1016/j.heliyon.2024.e39740

Table 8.

Association between 14-bp I/D polymorphism and cancers: Subgroup analysis according to viral infection.

Genetic models	Viral infection	Effect size and 95 % interval					Heterogeneity
Genetic models	Viral infection	N	OR	Lower limit	Upper limit	P-value	I²	P-het	τ²	P-Begg	P-Egger
D vs. I	Viral infections-	3	1,523	1,002	2,316	0,049	67,63	0,046	0,092	NS	NS
	Viral infections+	4	1,555	1,031	2,346	0,035	76,35	0,005	0,132	NS	0,006
DD vs. DI + II	Viral infections-	3	1,403	1,011	1,947	0,043	0,00	0,894	0,000	NS	NS
	Viral infections+	4	1,438	1,116	1,853	0,005	0,00	0,500	0,000	NS	NS
DD + DI vs. II	Viral infections-	3	2,412	0,610	9,536	0,209	87,72	0,000	1,291	NS	NS
	Viral infections+	4	2,163	0,704	6,646	0,178	85,47	0,000	1.077	NS	0,035
DD + II vs. DI	Viral infections-	3	0,817	0,354	1,887	0,636	84,07	0,002	0,456	NS	NS
	Viral infections+	4	1,040	0,632	1,711	0,878	69,54	0,020	0,175	NS	NS
DI vs II	Viral infections-	3	2,207	0,481	10,125	0,308	88,58	0,000	1,602	NS	NS
	Viral infections+	4	1,830	0,571	5,866	0,309	84,70	0,000	1,155	NS	0,029
DD vs II	Viral infections-	3	2,551	0,745	8,742	0,136	81,78	0,004	0,964	NS	NS
	Viral infections+	4	2,421	0,804	7,288	0,116	83,13	0,000	1,003	NS	0,046
DD vs DI	Viral infections-	3	1,218	0,855	1,733	0,275	0,00	0,684	0,000	NS	NS
	Viral infections+	4	1,399	1,065	1,839	0,016	0,00	0,892	0,000	NS	NS

Bold: significant P-value (<0,05); N: number of studies; NS: Not Significant; OR: odds ratio; I² : heterogeneity test; τ² , tau-squared; I/D : insertion/deletion; P- het, p-heterogeneity ; bp: base pairs. The overall analysis gives estimations among subgroups; Viral infection+: presence infection; Viral infection-: absence infection.