Table 4.

Multivariate analysis for COVID-19 positivity across different variant waves, from June 2020 to December 2022.

Multivariate model for SARS-CoV-2 positivity
	Ancestral	Gamma	Delta	Omicron BA.1	Omicron BA.2
Anosmia	2.47 [2.09–2.92]	2.57 [2.01–3.27]	3.76 [2.89–4.90]	N/A	N/A
Ageusia	1.56 [1.32–1.85]	1.35 [1.06–1.72]	NS	N/A	N/A
Headache	NS	NS	NS	N/A	N/A
Nasal congestion	NS	N/A	1.26 [1.06–1.49]	NS	N/A
Runny nose	0.66 [0.59–0.74]	0.64 [0.56–0.74]	0.84 [0.71–0.99]	NS	N/A
Diarrhea	N/A	N/A	N/A	0.62 [0.54–0.72]	0.59 [0.40–0.86]
Dyspnea	0.47 [0.35–0.65]	N/A	N/A	N/A	0.62 [0.43–0.89]
Sore throat	0.77 [0.69–0.86]	0.66 [0.58–0.76]	0.56 [0.48–0.66]	1.36 [1.21–1.52]	N/A
Myalgia	1.37 [1.21–1.54]	NS	1.50 [1.27–1.76]	1.17 [1.04–1.32]	N/A
Fatigue	NS	N/A	0.74 [0.64–0.87]	N/A	N/A
Fever	1.57 [1.40–1.76]	1.63 [1.42–1.87]	1.78 [1.53–2.06]	1.16 [1.03–1.30]	N/A
Nausea	N/A	0.67 [0.56–0.80]	N/A	0.74 [0.65–0.85]	N/A
Cough	1.40 [1.24–1.58]	1.39 [1.18–1.62]	1.77 [1.47–2.13]	1.33 [1.16–1.52]	N/A

∗NS (Not Significant) - parameter analyzed in a given wave, but with no statistically significant results. N/A (Not applicable) - parameter not analyzed in this model in a given wave, as it was not significant in the previous model.