Table 3.
Comparison of secondary outcomes and safety outcomes among groups.a.
| Group A (Low dose) |
Group B (High dose, short duration) |
Group C (High dose, long duration) |
P | |
|---|---|---|---|---|
| N = 126 | N = 44 | N = 40 | ||
| Intensive Care Unit admission | 42 (33.3 %) | 17 (38.6 %) | 10 (25.0 %) | 0.42 |
| Duration of Intensive Care Unit stay (Days) | 13 (6–18) | 16 (9–26) | 8 (4–16) | 0.12 |
| Extutbaion | 24 (56 %) | 5 (26 %) | 3 (38 %) | 0.081 |
| Extubation in 28 days | 22 (51 %) | 5 (26 %) | 3 (38 %) | 0.2 |
| Duration of invasive mechanical ventilation (Days) | 11 (5–19) | 13 (8–26) | 12 (5–21) | 0.60 |
| Safety outcomes | ||||
| Shock | 35 (27.8 %) | 17 (38.6 %) | 9 (22.5 %) | 0.26 |
| Infection | 32 (25.4 %) | 18 (40.9 %) | 13 (32.5 %) | 0.14 |
| Bloodstream infection | 10 (7.9 %) | 6 (13.6 %) | 3 (7.5 %) | 0.50 |
| Hospital acquired pneumonia | 20 (15.9 %) | 10 (22.7 %) | 6 (15.0 %) | 0.56 |
| Ventilator-associated pneumonia | 10 (7.9 %) | 5 (11.4 %) | 1 (2.5 %) | 0.31 |
| Fungal infection | 17 (13.5 %) | 11 (25.0 %) | 9 (22.5 %) | 0.13 |
| Gastrointestinal bleeding | 8 (6.3 %) | 3 (6.8 %) | 2 (5.0 %) | 1.00 |
| Delirium | 4 (3.2 %) | 3 (6.8 %) | 0 (0.0 %) | 0.21 |
| Venous thromboembolism | 14 (11.1 %) | 8 (18.2 %) | 11 (27.5 %) | 0.042b2 |
a
Data are presented as median (interquartile range) or n (percentage) as appropriate.
b2
P < 0.05 between Group A and Group C.