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. 2024 Nov 18;31(2):31. doi: 10.3892/mmr.2024.13397

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Copyright: © 2024 Jiao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Effect of low expression of MDM2 on HUVECs treated with ox-LDL. (A) The expression of MDM2 in HUVECs treated with 40 µg/ml ox-LDL detected by RT-qPCR. (B) The expression of MDM2 in HUVECs knocked down by si-MDM2 detected by RT-qPCR. (C) The effect of MDM2 knockdown on HUVECs proliferation detected by cloning assay. (D) The effect of MDM2 knockdown on HUVECs migration detected by wound healing assay. (E) Effect of MDM2 knockdown on HUVECs invasion detected by Transwell assay. Magnification 200×. (F) The effect of MDM2 knockdown on HUVECs apoptosis detected by flow cytometry. (G) The effect of MDM2 knockdown on HUVECs angiogenic ability detected by tube formation assay. Magnification, 200×. **P<0.01, ***P<0.001. MDM2, murine double minute-2; HUVECs, human umbilical vein endothelial cells; ox-LDL, oxidized low-density lipoproteins; RT-q-PCR, reverse transcription-quantitative PCR; si, short interfering.