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. 2024 Nov 18;31(2):31. doi: 10.3892/mmr.2024.13397

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Copyright: © 2024 Jiao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — PTEN participates in DVT by inhibiting JAK/STAT signaling pathway. (A) PTEN gene-related signaling pathways analyzed by KEGG. (B) The interaction between PTEN and JAK/STAT pathways analyzed by STRING. (C) The expression level of JAK/STAT signaling pathway associated proteins in HUVECs treated with ox-LDL (40 µg/ml) detected by western blotting. ***P<0.001, ^#P<0.05, ^##P<0.01. PTEN, phosphatase and tensin homolog; DVT, deep vein thrombosis; JAK, Janus kinase; STAT, signal transducer and activator of transcription; STRING, Search Tool for the Retrieval of Interacting Genes/Proteins; KEGG, Kyoto Encyclopedia of Genes and Genomes; HUVECs, human umbilical vein endothelial cells; ox-LDL, oxidized low-density lipoproteins; p-, phosphorylated; NC, negative control.