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. 2024 Nov 18;31(2):31. doi: 10.3892/mmr.2024.13397

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Copyright: © 2024 Jiao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — Effect of PTEN on HUVECs treated with ox-LDL mediated by inhibiting JAK/STAT signaling pathway. (A) Effect of AG-490 on HUVEC proliferation detected by cloning assay. (B) Effect of AG-490 on HUVEC migration detected by wound healing assay. Magnification 200×. (C) The effect of AG-490 on HUVECs invasion detected by Transwell assay. Magnification 200×. (D) The effect of AG-490 on HUVECs apoptosis detected by flow cytometry. (E) The effect of AG-490 on HUVECs angiogenic ability detected by tube formation assay. Magnification 200×. **P<0.01, ^#P<0.05, ^##P<0.01. PTEN, phosphatase and tensin homolog; HUVECs, human umbilical vein endothelial cells; ox-LDL, oxidized low-density lipoproteins; JAK, Janus kinase; STAT, signal transducer and activator of transcription; NC, negative control; si, short interfering.