Table 2.

Multivariable Cox regression model testing the associations between baseline sNfL z-score and sGFAP levels and the risk of first relapse appearance since o initiation.

	First relapse since OCR
	HR [95% CI]	p-Value
Age	1.005 [0.914–1.105]	0.919
Sex (male)	0.289 [0.315–2.642]	0.271
Disease duration (years)	1.003 [0.887–1.136]	0.951
Relapses in previous year	0.686 [0.244–1.924]	0.474
Baseline EDSS	0.786 [0.357–1.730]	0.550
Baseline T2 lesion load	0.937 [0.309–2.838]	0.908
Baseline sNfL, z-score	2.116 [1.119–3.999]	0.021
Baseline sGFAP, pg/ml	0.999 [0.993–1.005]	0.768

Multivariable model was adjusted by age, sex, disease duration, relapses in previous year, baseline EDSS and T2 lesion load. Bold highlight indicates statistically significant values. OCR, ocrelizumab initiation; HR, hazard ratio; CI, confidence interval; EDSS, Expanded Disability Status Scale; sNfL, serum neurofilament light chain; sGFAP, serum glial fibrillary acidic protein.