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. 1999 May;67(5):2567–2574. doi: 10.1128/iai.67.5.2567-2574.1999

FIG. 1.

FIG. 1

Bacterium-induced Ca2+ signaling in human neutrophils. Time course of [Ca2+]i in a single neutrophil upon infection with Y. pseudotuberculosis plasmid-cured bacteria. The plasmid-cured strain was added to adherent neutrophils at a calculated bacterium/cell ratio of 50:1 (arrow). The “✗” symbol indicates contact between a bacterium and the neutrophil. Attachment of bacteria was visually observed on a video screen, and this was correlated to the [Ca2+]i transients. A representative time course is presented (of 12 separate experiments), together with some selected images in pseudocolor (time points are indicated in the graph). The phase images show the attachment of a single bacterium (indicated by an arrow) to the same neutrophil shown in the pseudocolor image situated above. The mean number of [Ca2+]i transients is shown in Table 2.