Table 4.

Number of differentially enriched gene sets and percentage included in pathogenically significant processes

	Expression changes as compared to controls
		SKIN		BLOOD
		n	Biological categories	n	Biological categories
Infested altogether	Up	26	Immunity and inflammation (65%): - Response to cytokine (23%) - Response to other organisms (15%) - Immune system processes (15%) - Cytokine production (8%) - Inflammatory response (4%)	383	Immunity and inflammation (22%): - Response to cytokine (1%) - Response to other organisms (2%) - Immune system processes (9%) - Cytokine production (5%) - Inflammatory response (2%) Response to wounding (3%)
	Down	209	Cell division (32%): - Chromosome organization (10%) - DNA metabolic processes (12%) - RNA metabolic processes (1%) - Cell cycle (8%) - Cell division (1%) Pigmentation (4%) Response to radiation (1%) Immunoglobulin production (2%)	316	Cell division (50%): - Chromosome organization (8%) - DNA metabolic processes (14%) - RNA metabolic processes (20%) - Cell cycle (3%) - Gene expression (5%) Response to radiation (3%)
- Recovered	Up	21	Immunity and inflammation (24%): - Leukocyte differentiation (19%) - Response to chemokine (5%) Cell division—Gene expression (14%) Protein folding (19%) Response to topologically incorrect protein (19%)	87	Immunity and inflammation (2%): - Leukocyte migration (1%) - Response to other organisms (1%) Response to wounding (2%) Coagulation (5%)
	Down	50	Cell division (16%): - Chromosome organization (8%) - DNA metabolic processes (8%) Metabolic processes (62%) Pigmentation (12%)	306	Cell division (41%): - Chromosome organization (7%) - DNA metabolic processes (7%) - RNA metabolic processes (21%) - Cell cycle (1%) - Gene expression (5%) Response to radiation (1%) Immunity and inflammation (11%): - Immune system processes (9%) - Cytokine production (2%)
- Severely infested	Up	14	Immunity and inflammation (79%): - Response to cytokine (29%) - Cytokine production (14%) - Response to other organisms (29%) - Lymphocyte migration (7%)	249	Immunity and inflammation (22%): - Cytokine production (8%) - Leukocyte processes (7%) - Innate immune response (3%) - Inflammatory response (2%) - Response to other organisms (2%) Response to wounding (2%) Coagulation (1%)
	Down	209	Cell division (36%): - Cell cycle (11%) - Cell division (1%) - Chromosome organization and segregation (11%) - DNA metabolic processes (10%) - RNA metabolic processes (3%) Immune system processes (2%) Pigmentation (4%)	700	Cell division (62%): - Chromosome organization (9%) - DNA metabolic processes (20%) - RNA metabolic processes (24%) - Cell cycle (4%) - Gene expression (5%) Metabolic processes (13%) Immune system processes (4%) Response to radiation and UV (3%) Pigmentation (1%)

The differences are presented between the control and the infested Iberian ibexes (Capra pyrenaica), both as a whole and for each of the different clinical outcomes. Data obtained using the GO biological process collection in the GSEA analysis (nominal p-value < 0.05 and FDR < 0.1) both in skin and blood