Table 2.
LASSO COX regression analyses constructing three radiomics scores for predicting bRFS in patient with non-metastatic PCa receiving RP treatment
| ROIs | MRI sequences | Group and filters | Feature class | Feature | Coef |
|---|---|---|---|---|---|
| Periprostatic fat radiomics features | |||||
| Periprostatic fat | ADC | Wavelet (HLL) | GLSZM | Large Area High Gray Level Emphasis | 0.349 |
| T2WI | Wavelet (HLL) | NGTDM | Contrast | −2.132 | |
| ADC | Wavelet (HHH) | GLSZM | Small Area Emphasis | 0.661 | |
| T2WI | Original | Shape | Major Axis Length | 0.839 | |
| ADC | LoG (sigma = 3.0.mm 3D) | GLCM | Sum Squares | 2.613 | |
| ADC | Wavelet (HHH) | GLCM | Idn | 1.160 | |
| T2WI | Wavelet (LHH) | GLSZM | Zone Variance | 0.777 | |
| T2WI | Wavelet (HLH) | GLSZM | Large Area Emphasis | −0.343 | |
| Intratumoral radiomics features | |||||
| Intratumoral region | ADC | wavelet (LHH) | First order | Interquartile Range | 0.837 |
| ADC | Wavelet (HLL) | First order | Skewness | 0.000 | |
| ADC | Wavelet (HHL) | GLCM | Joint Energy | 0.328 | |
| ADC | LoG (sigma = 5.0.mm 3D) | GLRLM | Run Length Non Uniformity Normalized | 0.183 | |
| ADC | LoG (sigma = 2.0.mm 3D) | GLCM | Sum Entropy | 0.180 | |
| T2WI | Wavelet (LLL) | GLCM | Idn | −0.002 | |
| Periprostatic fat-intratumoral radiomics features | |||||
| Periprostatic fat | T2WI | Wavelet (HLL) | NGTDM | Contrast | −0.708 |
| Periprostatic fat | ADC | wavelet (HHH) | GLSZM | Small Area Emphasis | 0.215 |
| Periprostatic fat | T2WI | Original | Shape | Major Axis Length | 0.327 |
| Periprostatic fat | ADC | LoG (sigma = 3.0.mm 3D) | GLCM | Sum Squares | 0.869 |
| Periprostatic fat | T2WI | Wavelet (LHH) | GLSZM | Zone Variance | 0.072 |
| Intratumoral region | ADC | Wavelet (LHH) | First order | Interquartile Range | 0.713 |
| Intratumoral region | ADC | LoG (sigma = 5.0.mm 3D) | GLRLM | Run Length Non Uniformity Normalized | 0.448 |
| Intratumoral region | ADC | LoG (sigma = 3.0.mm 3D) | GLCM | Imc2 | 0.035 |
LASSO The Least absolute shrinkage and selection operator, bRFS biochemical recurrence-free survival, PCa Prostate cancer, RP radical prostatectomy, ROIs Regions of interests, MRI Magnetic resonance imaging, Coef Coefficient, ADC Apparent-diffusion coefficient, T2WI T2-weighted imaging, GLSZM Gray-level size zone matrix, NGTDM neighboring gray tone difference matrix, GLCM Gray-level co-occurrence matrix, GLRLM Gray-level run length matrix, LoG Laplacian of Gaussian