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A-B) Insulin secretion in vitro for male (A) and female (B) at low (3mmol/L) and high (17mmol/L) glucose concentrations. C) Stimulation index, calculated as the ratio of insulin secreted at 17 mmol/L glucose to that at 3 mmol/L glucose, from pooled islets of both sexes across genotypes. One-way ANOVA of Brown-Forsythe. Mean ± SD. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.
