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[Preprint]. 2024 Nov 15:2024.11.13.623456. [Version 1] doi: 10.1101/2024.11.13.623456

Figure 3. cPRC1.2 loops target bivalent promoters for gene activation upon differentiation.

Figure 3.

a, Distribution of Pcgf2-dependent loop regions relative to the nearest annotated transcription start site (TSS). The x-axis represents the distance to TSS. b, ChIP-seq signal showing H3K27me3 and H3K4me3 enrichment across all loop regions (left panel) and cPRC1.2 loop regions (right panel) in WT ESCs. c, Percentage of bivalent domains within total Pcgf2 targets, non-loop Pcgf2 targets, and cPRC1.2 loop targets. d, Box plots showing expression of neural-ectoderm genes (82) and non-neural-ectoderm genes (372) that are targeted by cPRC1.2 loops in WT and Pcgf2−/− cells across ESC, EB, and NPC stages. **p<0.01; *** p<0.001; n.s., not significant.