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[Preprint]. 2024 Nov 15:2024.11.12.623270. [Version 1] doi: 10.1101/2024.11.12.623270

Figure 3. Validation of IL1B association with smaller reservoir size from an independent cohort with a different infecting viral subtype across various Fiebig stages.

Figure 3.

A) HIV DNA levels vary within the A5354 subtype B cohort from the USA (n=38). The participant samples used in this study are highlighted based on reservoir size: red=detectable; teal=undetectable and yellow=middle. Black and White indicate differences in ancestry of the participants. B) Characteristics of participants comprising the detectable, middle, and undetectable reservoir size categories (mean values are shown) and p values comparing the extreme phenotype groups. HIV-1 subtype information was only available for a subset of the participants. NS: not significant C) Dimensionality reduction plot of the different immune clusters in this cohort. D) CD14+ monocytes have the highest number of normalized DEG associated with reservoir size using a continuous analysis including all 38 participants. E) IL1B participant-specific average gene expression in CD14+ monocytes categorized by total HIV DNA (n=38). Spearman correlation p value and rho are shown. F) IPDA® measurements from a subset of the participants in this cohort (n=21). G) IL1B association with different reservoir type measurements (rows) from the participants with IPDA measurements (n=21).