Figure 2: XEC exhibits strong nAb escape.

NAb titers were determined using a HIV-1 pseudotyped vector neutralization assay for three cohorts of sera. (A-B) OSU Wexner Medical Center healthcare workers that received 3 doses of monovalent (WT) mRNA vaccine and 1 dose of bivalent (WT + BA.4/5) mRNA vaccine (n=8). (C-D) COVID-19 patients at the OSU Wexner Medical Center that were admitted during the BA.2.86/JN.1 wave of infection in Columbus, OH (n=9). (E-F) Golden Syrian hamsters vaccinated twice with a monovalent, recombinant Mumps XBB.1.5 mRNA vaccine (n=9). (A, C, and E) Plots represent geometric mean nAb titers at 50% (NT₅₀) with standard error. Geometric mean values are listed at the top of the plots and significance was determined in comparison to JN.1 unless otherwise noted. Fold changes relative to JN.1 are listed above the geometric mean values. (B, D, and F) Heatmaps depicting the nAb titers for each individual in each cohort. Significance was determined in (A, C, and E) using log10 transformed NT₅₀ values using repeated measures one-way ANOVA and represented as ns p > 0.05, *p < 0.05, and ****p < 0.0001.