Figure 3: Analysis of antigenicity of XEC and related variants.

(A-C) Antigenic cartography analysis was conducted for the nAb titers results for the bivalent vaccinated HCWs (A), the BA.2.86/JN.1 wave infected patients (B), and the XBB.1.5-monovalent vaccinated hamsters (C). One antigenic distance unit (AU) (AU = 1) represents an approximate two-fold change in NT₅₀. Circles represent the different spike antigens while boxes represent individual sera samples. (D) The antigenic distances of each variant relative to JN.1 from three groups of cohorts (n=3) were averaged and plotted. The scale bar represents 1 antigenic distance unit (AU).