TABLE 1.
Vaccine-induced protection of guinea pigs as measured by M. bovis CFUa
| Immunization group (no. of animals) | Lung
|
Spleen
|
Liver
|
|||
|---|---|---|---|---|---|---|
| Log10 CFU (mean ± SE) | Log10 protection | Log10 CFU (mean ± SE) | Log10 protection | Log10 CFU (mean ± SE) | Log10 protection | |
| Nonvaccinated (10) | 5.27 ± 0.1 | 0 A | 5.04 ± 0.19 | 0 A | 3.17 ± 0.17 | 0 A |
| BCG (8) | 4.33 ± 0.21 | 0.94 B | 1.76 ± 0.38 | 3.28 BC | 0.8 ± 0.09 | 2.38 C |
| WAg520 (6) | 4.35 ± 0.32 | 0.92 B | 1.21 ± 0.36 | 3.83 C | 0.7 ± 0 | 2.47 C |
| WAg521 (5) | 4.34 ± 0.28 | 0.92 AB | 3.3 ± 0.09 | 1.74 B | 1.84 ± 0.26 | 1.33 B |
| WAg522 (4) | 3.98 ± 0.12 | 1.28 B | 1.87 ± 0.61 | 3.17 BC | 0.7 ± 0 | 2.48 C |
| WAg523 (5) | 4.39 ± 0.22 | 0.88 AB | 2.35 ± 0.55 | 2.69 BC | 0.95 ± 0.14 | 2.23 C |
a
Values within columns followed by the same letter are not significantly different (P > 0.05). The minimum detectable level was 0.7 log10.