Table 2. Meta-Analysis Results: Top Differentially Expressed Genes (FDR<0.10) in the PFC of Adult Rodents That Had Experienced ELS.
Rows highlighted with bold text denote genes that are significantly differentially expressed (FDR<0.05), all other genes show a trend towards differential expression (FDR<0.10). The rows are ordered by Log2FC (lowest to highest). Definitions: Log2FC = Log2 Fold Change (ELS vs. Control), SE = Standard Error, CI_lb=confidence interval lower bound, CI_ub=confidence interval upper bound, p-value = nominal p-value, FDR = False Discovery Rate (q-value). A positive Log2FC denotes that a gene’s expression is higher in the experimental group compared to the control group (upregulated: highlighted grey), with higher positive values indicating greater increases. A negative Log2FC indicates lower expression in the experimental group relative to the control (downregulated), where larger negative values signify more substantial decreases. The # of comparisons represents the number of datasets that included measurements for the gene following quality control.
| Rat Entrez Gene ID | Mouse Entrez Gene ID | Gene Symbol | Log2FC estimate | SE | CI_lb | CI_ub | P-value | # of Comparisons | FDR |
|---|---|---|---|---|---|---|---|---|---|
| 293711 | 66727 | Plaat5 | −0.62 | 0.15 | −0.92 | −0.33 | 3.41E-05 | 4 | 0.05543 |
| 310621 | 404710 | Iqgap3 | −0.54 | 0.12 | −0.77 | −0.30 | 5.38E-06 | 4 | 0.02133 |
| 25654 | 12814 | Col11a1 | −0.48 | 0.11 | −0.70 | −0.26 | 2.10E-05 | 4 | 0.04998 |
| 29245 | 19144 | Klk6 | −0.45 | 0.11 | −0.67 | −0.24 | 4.66E-05 | 4 | 0.05543 |
| 24827 | 21802 | Tgfa | −0.35 | 0.06 | −0.47 | −0.22 | 9.60E-08 | 4 | 0.00114 |
| 307855 | 338521 | Fa2h | −0.30 | 0.08 | −0.45 | −0.15 | 9.18E-05 | 4 | 0.08395 |
| 84588 | 18417 | Cldn11 | −0.30 | 0.06 | −0.42 | −0.18 | 1.10E-06 | 5 | 0.00653 |
| 114004 | 68458 | Ppp1r14a | −0.29 | 0.08 | −0.44 | −0.14 | 1.31E-04 | 5 | 0.09155 |
| 680723 | 320587 | Tmem88b | −0.29 | 0.07 | −0.43 | −0.14 | 1.20E-04 | 4 | 0.09155 |
| 25263 | 17153 | Mal | −0.28 | 0.07 | −0.42 | −0.15 | 4.60E-05 | 5 | 0.05543 |
| 29409 | 17136 | Mag | −0.26 | 0.06 | −0.37 | −0.14 | 1.56E-05 | 5 | 0.04639 |
| 83626 | 22234 | Ugcg | 0.09 | 0.02 | 0.04 | 0.13 | 8.62E-05 | 5 | 0.08395 |
| 302032 | 232566 | Amn1 | 0.09 | 0.02 | 0.04 | 0.14 | 1.28E-04 | 4 | 0.09155 |
| 308718 | 18634 | Pex7 | 0.09 | 0.02 | 0.05 | 0.14 | 9.12E-05 | 5 | 0.08395 |
| 361006 | 76670 | Cfap70 | 0.23 | 0.06 | 0.11 | 0.35 | 1.30E-04 | 4 | 0.09155 |
| 25253 | 13482 | Dpp4 | 0.33 | 0.08 | 0.18 | 0.49 | 3.23E-05 | 4 | 0.05543 |
| 100363095 | 66715 | Henmtl | 0.40 | 0.10 | 0.21 | 0.59 | 4.26E-05 | 4 | 0.05543 |