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. 2024 Nov 8;9(21):e173052. doi: 10.1172/jci.insight.173052

Figure 3. Auditory brainstem responses (ABR) and vestibular-evoked potentials (VsEP) after artificial perilymph injection through the PSCC reveal no long term effects.

Figure 3

(A) ABR thresholds in preinjection and 2-week-postinjection conditions (n = 8). P > 0.05 by paired, 2-tailed Student’s t test. (B) ABR wave 1 amplitude at 8, 16, and 32 kHz in preinjection and 2-week-postinjection conditions (n = 8). P > 0.05 by paired, 2-tailed Student’s t test. (C) Representative VsEP responses in non-injected mice (left ear; non-surgery) and (D) 2 weeks after artificial perilymph (AP) injected mice (right ear). Orange lines indicate thresholds of the VsEP responses. (E) VsEP thresholds in non- (n = 7; 4 females and 3 males) and AP-injected (n = 7; 4 females and 3 males) groups with preinjection and 2-week-postinjection conditions. The thresholds are not significantly different between preinjection and 2-week-postinjection conditions (P > 0.05 by paired, 2-tailed Student’s t test) as well as non- and 2-week-postinjection conditions (P > 0.05 by unpaired, 2-tailed Student’s t test). No statistical difference between sexes was also detected (P > 0.05 by unpaired, 2-tailed Student’s t test). The error bars indicate the variation of the threshold decisions by 4 researchers. Boxes are SD; stars are the means across animals.