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. 2024 Nov 8;9(21):e179126. doi: 10.1172/jci.insight.179126

Figure 8. Astrogliosis and microgliosis occur within Gba-nKO mice.

Figure 8

(A) Representative images of immunofluorescence staining of microglia (Iba1) in the cortex, hippocampus, thalamus, cerebellum, and brain stem of Gba-nKO mice. (B) Representative images of immunofluorescence staining of astrocytes (GFAP) in the cortex, hippocampus, thalamus, cerebellum, and brain stem of Gba-nKO mice. (C and D) Quantification of Iba1 (C) and GFAP (D) fluorescence in Gba-nKO mice compared with age-matched controls. (E) An example of a microglial nodule present within Gba-nKO mice. Gba-nKO brains were collected at 15–18 weeks. Scale bars: 50 μm (A and B); 25 μm (E). Unpaired t test. n = 6. **P < 0.01.