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[Preprint]. 2024 Nov 19:2024.11.19.624190. [Version 1] doi: 10.1101/2024.11.19.624190

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Figure 3. — (A) Cp kidney cells immortalized by SV40 T-antigen (CaPsm-K SV40T) were infected with replication competent VSV (rVSV) pseudotyped with indicated orthohantavirus glycoproteins. Neutralization of rVSV ANDV and HTNV with soluble PCDH1 receptor (sEC1–2) on Cp kidney cells (B), and human U2OS cells for comparison (C). (D) Neutralization of rVSV-ANDV and HTNV on Cp kidney cells by preincubation of cells with an anti-PCDH1 (mAb-3305) antibody. (E) Neutralization of rVSV ANDV by mAb-3305 on human pulmonary microvascular endothelial cells (HPMEC) is shown as a positive control. To rule out the possibility that mAb-3305 fails to block rVSV-ANDV infection in Cp kidney cells due to rapid uptake/clearance of the antibody, the experiment was performed on ice.