Figure 2. Conformational ensembles predict metamorphic domains within Lassa GPC.

(A) Superimposed predicted structures for uncleaved monomers for Lassa josiah strain highlight conformational plasticity within NFP, IFL and HR1 domains. (B) Superimposed predicted structures of post-fusion conformation highlighting conformational plasticity within NFP, IFL and T-loop during the post-fusion stage. (C) Trajectory analysis for all predicted structures showing conformationally dynamic regions of lassa GPC at different MSA subsamples (as denoted by varying lines). The known domains of GP2 are color-coded: NFP (red); IFL (orange); HR1 (yellow); T-loop (green); HR2 (blue); MPER (purple).