Figure 1. Integration of phenotyping and genotyping assessment of a diverse set of IIDP-derived human islet preparations.

(A) Schematic illustrating the human islet phenotyping and genotyping pipelines utilized by the HIPP and HIGI. The HIPP performs analysis of islet morphology, purity, viability, histology, and function; the remaining sample is archived in a biorepository for additional analyses. The HIGI receives a non-islet tissue sample and isolates DNA to sequence for genetic ancestry prediction and calculation of genetic risk scores for type 1 and type 2 diabetes. (B) Descriptive statistics of donor demographics by sex and reported race or ethnicity (n = 299). Values are reported as mean ± standard deviation, followed by the range. (C) Descriptive statistics of donor demographics by sex and primary predicted ancestry (n = 268). Values are reported as mean ± standard deviation, followed by the range. **p < 0.01 vs. male donors; ***p < 0.001 vs. male donors.