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[Preprint]. 2024 Nov 21:2024.11.20.623809. [Version 1] doi: 10.1101/2024.11.20.623809

Figure 6. Islet composition and hormone content are highly variable and influenced by donor sex and ancestry.

Figure 6.

(A) Representative images of collagen gel-embedded islets and associated quantification of islet composition (n = 299). Violin plots comparing islet composition by (B) donor sex, (C) reported race or ethnicity, and (D) predicted primary genetic ancestry. (E) Islet insulin content normalized to IEQ (n = 299). Violin plots comparing islet insulin content by (F) donor sex, (G) reported race or ethnicity, and (H) predicted primary genetic ancestry. (F) Islet glucagon content normalized to IEQ (n = 299). Violin plots comparing islet glucagon content by (J) donor sex, (K) reported race or ethnicity, and (L) predicted primary genetic ancestry. Donor sex: n = 115 female, n = 184 male. Reported race or ethnicity: n = 12 Asian, n = 26 Black or African American, n = 86 Hispanic or Latino/a, n = 175 White. Primary predicted genetic ancestry: n = 86 Admixed American, n = 21 African, n = 11 East Asian, n = 150 European. *p < 0.05, **p < 0.01. For sex, reported race or ethnicity, and genetic ancestry, the global adjusted p-value is based on the F-test while controlling for the other seven covariates. INS – insulin; GCG – glucagon; SST – somatostatin.