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[Preprint]. 2024 Nov 13:2024.11.13.24317257. [Version 1] doi: 10.1101/2024.11.13.24317257

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Extended Data Figure 5. — Cell type and state regulation of molecular traits. Pseudobulk accessibility by genotype plots for (a) ADAMTS7, (b) NEK9, (c) SMAD7, and (d) FDX are cell type specific caQTLs for SMCs, endothelium, fibroblasts and myeloid cells respectively. (e) DotPlot of canonical marker genes for endothelium cell biology grouped by mapped cell state annotation. (f) Pathway enrichment for statistically significant genes upregulated in EndoMT (adjusted p-value < 0.05 and log2FC > 0.58). (g) Endothelium acting loci from V2G2P in Schnitzler et al⁴⁷ gene set score grouped by EC state. (h) Program 8 gene set score from Schnitzler et al⁴⁷ in UMAP embedding plot (left) and DotPlot grouped by EC state (right).