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[Preprint]. 2024 Nov 13:2024.11.13.24317257. [Version 1] doi: 10.1101/2024.11.13.24317257

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Extended Data Figure 6. — Dynamic caQTL modeling. (a) SMCs integrated from Turner et al³⁴ and Multiome snATAC-seq to construct a meta-map for dynamic single cell QTL modeling grouped by dataset. (b) FMC marker genes gene activity score split by dataset. (c) Framework for single cell dynamic caQTL modeling with a Poisson Mixed Effect model showing an FMC state dependent effect of genotype on chromatin accessibility. (d) Gene set score for dynamic caQTLs overlapped with CAD GWAS variants linked to genes with scE2G grouped by SMC state. (e) HSD52 betas for dynamic caQTL at rs658956 in UMAP embedding (left) and pseudobulk box plots by genotype and FMC score tertile (right).