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. 2005 Jun 27;33(Web Server issue):W589–W591. doi: 10.1093/nar/gki419

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© The Author 2005. Published by Oxford University Press. All rights reserved

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(A) Biochemical process of dsRNA-mediated RNAi. Off-target effects are caused by ‘diced’ siRNAs that have sequence similarities with unrelated genes. (B) The output for the 1497 bp query sequence of the Drosophila pdm2 gene (NM_078834, coding region). Significant hits against two off-target genes, nub (NM_057311) and vvl (NM_079224) were detected. (C) pdm, nub and vvl share a highly conserved POU domain. Each dot represents a position with 17/19 or more matches.