Skip to main content
[Preprint]. 2024 Nov 13:rs.3.rs-5040415. [Version 1] doi: 10.21203/rs.3.rs-5040415/v1

Table 5.

Time to detect progression according to different scenarios of optical coherence tomography retinal nerve fiber layer thickness loss over time, by race and ethnicity, assuming annual testing.

BY RACE
Baseline disease severity, μm “True” rates of change, μm/year Mean time to detect progression, Mean ± SD, years Difference in time to detect progression in 80% of eyes (80% power), years

Black or African American White P value Black or African American versus White Subjects

90 −0.5 10.2 ± 5.3 10.0 ± 5.3 0.291 0.2

−1.0 6.6 ± 2.3 6.4 ± 2.2 0.003 0.3

−2.0 4.7 ±1.4 4.4 ±1.4 0.000 0.3

70 −0.5 10.0 ± 5.6 9.6 ± 5.7 0.184 0.2

−1.0 6.4 ± 2.1 5.9 ±1.8 0.000 0.7

−2.0 4.4 ±1.2 4.1 ±1.2 0.000 0.3

BY ETHNICITY
Baseline disease severity, μm “True” rates of change, μm/year Mean time to detect progression, Mean ± SD, years Difference in time to detect progression in 80% of eyes (80% power), years

Hispanic or Latino Not Hispanic or Latino P value Hispanic or Latino versus
Not Hispanic or Latino

90 −0.5 9.6 ± 5.4 10.6 ± 5.7 0.000 −1.3

−1.0 6.0 ± 2.0 6.5 ± 2.2 0.000 −0.7

−2.0 4.4 ±1.2 4.5 ±1.4 0.000 −0.3

70 −0.5 9.4 ± 5.6 9.5 ± 5.3 0.875 0.2

−1.0 5.9 ± 2.1 5.9 ±1.9 0.768 0.0

−2.0 4.2 ±1.1 4.2 ±1.2 0.383 0.0

SD = Standard deviation.