Figure 1.

Sankey plot demonstrating the TNM stage shift between conventional imaging and PSMA PET/CT staging and the potential impact on treatment decision change. Standard of care at the time of diagnosis for this cohort for stage T any N any M0 was radical treatment with up to 3 years of androgen deprivation therapy (ADT) and prostate ± loco-regional radiotherapy. For stage T any N any M1a was long-term ADT, additional systemic therapy with docetaxel or androgen receptor pathway inhibitors (ARPIs) and prostate only radiotherapy. For stage T any N any M1b was long-term ADT, additional systemic therapy and prostate only radiotherapy if 3 or fewer bone metastases were confirmed on conventional imaging. For stage T any N any M1c standard of care treatment was long-term ADT and additional systemic therapy.