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. 2024 Nov 1;8(12):ziae135. doi: 10.1093/jbmrpl/ziae135

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© The Author(s) 2024. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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X-ray microscopy imaging of lacunar volume and density in contralateral (uninjured) tibia. Group sizes: TG- Cntrl: 4, TG- Fx: 4, TG+ Cntrl: 4, TG+ Fx: 4. (a-b) Representative images of tibial cortical bone ROI for (A) BCL2 TG- and (B) BCL2TG+. (C) Cortical lacunar volume by genotype and fracture. (D) Trabecular lacunar volume by genotype and fracture. (E-H) Lacunar density and average lacunar volume for cortical and trabecular bone ROIs. BCL2 TG+ mice have higher lacunar density but average lacunar volume does not differ by genotype (E-H). ^*p < 0.05. Abbreviations: BCL2, B-cell lymphoma 2; TG-, non-transgenic; TG+, transgenic.