Figure 2.

Gene Ontology function and protein–protein interaction mapping with VisANT. The colored regions contain genes and proteins annotated in the SGD yeast GO as belonging to molecular function categories of transcription activators (peach), transcription repressors (blue), DNA binding (magenta) and signal transduction (green). These functional groups can be expanded or collapsed by double-clicking with the mouse. Dark black connections between GO categories indicate shared gene or protein components of these functions, e.g. the protein alien appears both in signal transduction and in transcription activation. Gray connections are protein–protein interactions determined by high-throughput yeast two-hybrid assay by Giot et al. (18). Interactions of other types can be loaded by the user from their own sources, or from other methods in the database.