Figure 10. Decreased abundance of MUC5B-associated oligosaccharides in LSGs from patients with SjD.

The oligosaccharide mixtures of MUC5B, obtained by reductive β-elimination in LSGs from individuals acting as controls (A) and patients with SjD (B), were also analyzed by UV-MALDI-TOF mass spectrometry. Signals for sulfated and nonsulfated oligosaccharides were detected; however, the abundance observed in samples from patients with SjD showed a substantial reduction (spectra are shown on different scales). O-glycan structures are depicted using the symbol nomenclature for glycans (SNFG).