Table 3. Status of the circulatory inflammatory milieu in patients with Post Kala-azar Dermal Leishmaniasis (PKDL).
| Cytokines | PKDL (pg/ml) [n = 20] |
Healthy controls (pg/ml) [n = 10] |
p value | Correlation (r) with lesional CD66b+ cells/field |
|---|---|---|---|---|
| IL-6 | 82.80 (20.64–167.7) |
7.71 (2.06–38.10) |
p<0.001 | r = -0.77 (ns) |
| IFN-γ | 71.63 (38.56–147.50) |
27.42 (21.94–30.39) |
p<0.01 | r = -0.79 (ns) |
| IL-4 | 61.25 (52.31–77.35) |
41.27 (24.97–50.40) |
p<0.01 | r = -0.25 (ns) |
| IL-10 | 143.50 (122.70–160.80) |
7.35 (5.69–13.34) |
p<0.0001 | r = 0.60, p<0.05 |
| IL-17 | 1.23 (1.04–1.86) |
1.07 (0.94–1.31) |
ns | r = -0.56 (ns) |
| IL-23 | 24.90 (17.39–35.56) |
20.15 (3.28–28.83) |
ns | r = 0.05 (ns) |
| IL-22 | 4.41 (3.12–5.74) |
3.43 (3.12–4.08) |
ns | r = 0.03 (ns) |
The levels of cytokines were measured and their correlation with CD66b+ neutrophils analysed as described in Materials and methods. ns: not significant. Values are stated in median (IQR).