Table 2. Longitudinal Disease Course.

Time point	Clinical findings	Laboratory data	Imaging findings	Treatment
Hospital admission (initial presentation)	Left face and hemibody paresthesias	CSF: mild leukocytosis, 5 CSF-specific oligoclonal bands	MRI brain: T2 FLAIR hyperintensity in the bilateral periventricular regions and right pons; cranial nerve enhancement	5-day course of high-dose IV methylprednisolone
	Abnormal gait with left leg dragging	Serum: positive anti-SSB antibody; no serum oligoclonal bands	MRI spine: enhancement in the cauda equina and thoracic nerve roots
	Weakness in left hip and knee
	Absent lower extremity reflexes
Hospital discharge (8 days post-admission)	Mild improvement in strength	No new laboratory findings	No new imaging findings	Discharged with follow-up to neuroimmunology and rheumatology
	Persistent left-sided paresthesias
2 months post-discharge	Improved motor exam	Serum: elevated salivary protein 1 IgM, elevated carbonic anhydrase VI IgG and IgM antibodies, elevated parotid specific protein IgA antibody	MRI brain: persistent enhancement of cranial nerves	3-day course of high-dose oral prednisone
	Residual numbness			Ofatumumab 20 mg monthly

CSF: cerebrospinal fluid; MRI: magnetic resonance imaging; FLAIR: fluid-attenuated inversion recovery; IV: intravenous; SSB: Sjogren’s syndrome B.