Figure 2.

Fc.Mut24 activates different Foxp3⁺ T_R cell subsets

(A) Number and proliferation (Ki-67) of CD25⁺ Foxp3⁺ T_R and the expression of indicated T_R activation markers. Gates were set on live, CD4⁺ cells.

(B) Percentage, number, and proliferation of CD44^lo CD62L^hi central T_R (cT_R), CD44^hi CD62L^hi central-effector T_R (ceT_R), and CD44^hi CD62L^lo effector T_R (eT_R) in each treatment group. Gates are indicated on representative flow-cytometry plots.

(C) Expression of indicated T_R activation markers on T_R subsets.

All graphs show mean ± SD with individual data points (n = 6–11); ^∗p ≤ 0.05, ^∗∗p ≤ 0.01, ^∗∗∗∗p ≤ 0.0001, two-tailed unpaired t tests, or multiple unpaired t tests. n.s., not significant. Data are representative of 2–3 independent experiments.