FIGURE 6.

Time courses and model fittings of brain deuterated glucose (Glc), glutamate/glutamine (Glx), and lactate (lac) concentrations in two rats ((A) rat A and (B) rat B) during and after d‐glucose‐6,6‐d₂ (D66) administration (indicated by shaded areas) using the modified kinetic model (Figure S2). The derived cerebral metabolic rate of glucose consumption (CMR_Glc), cerebral metabolic rate of the tricarboxylic acid cycle (V _TCA), and cerebral metabolic rate of lactate formation (CMR_Lac) values from the model fitting were 0.60, 1.16, and 0.05 μmol/g/min for rat A and 0.67, 1.17, and 0.17 μmol/g/min for rat B, respectively.