Extended Data Table 1.

Associations of NK2R variants R3232H (rs61732393-T), I23T (rs5030920-G), V54I (rs151093941-T) and A161T (rs148031991-T) with cardiometabolic traits and minor allele frequencies (MAF) in five different ancestries

African American (AFR), Admixed American (AMR), East Asian (EAS), European (EUR) and South Asian (SAS). The beta (effect size), standard error, p-value and sample size are from the largest published European study for each trait, referenced with their PubMed ID (PMID). The association tests were two-sided without multiple corrections. HbA1c: Glycated hemoglobin; Non-HDLc: Non High-Density Lipoprotein Cholesterol; HOMA-IR: homeostatic model assessment – insulin resistance; AST-ALT ratio: Aspartate transferase - alanine transaminase ratio; BMI: body mass index; WHR: Waist-hip ratio; ALT: Alanine transaminase.