Table 2.
Number of studies published assessing different methods of determining optimal positive end-expiratory pressure
| PEEP method* | Overall, n/total N (%) | Setting, n/total N (%)* | RCTs, n/total N (%)† | |
|---|---|---|---|---|
| ICU | OR | |||
| All studies | 271 | 216 | 55 | 73 |
| Compliance | 73/271 (27%) | 46/216 (21%) | 27/55 (49%) | 29/73 (40%) |
| Imaging-based | 65/271 (24%) | 51/216 (24%) | 14/55 (26%) | 11/73 (15%) |
| PEEP-FIO2 table | 53/271 (20%) | 52/216 (25%) | 0/55 (0%) | 21/73 (29%) |
| Esophageal probe | 49/271 (18%) | 41/216 (19%) | 8/55 (15%) | 11/73 (15%) |
| Oxygenation | 40/271 (15%) | 35/216 (16%) | 5/55 (9%) | 12/73 (16%) |
| Pressure-volume curves | 23/271 (9%) | 23/216 (11%) | 0/55 (0%) | 7/73 (10%) |
| Plateau pressure | 12/271 (4%) | 12/216 (6%) | 0/55 (0%) | 2/73 (3%) |
| Driving pressure | 11/271 (4%) | 5/216 (2%) | 6/55 (11%) | 7/73 (10%) |
| Computer-based | 11/271 (4%) | 11/216 (5%) | 0/55 (0%) | 1/73 (1%) |
| Shunt | 10/271 (4%) | 10/216 (5%) | 0/55 (0%) | 2/73 (3%) |
| Auto-PEEP | 8/271 (3%) | 8/216 (4%) | 0/55 (0%) | 0/73 (0%) |
| EELV/FRC | 7/271 (3%) | 5/216 (2%) | 2/55 (4%) | 1/73 (1%) |
| Dead space | 6/271 (2%) | 4/216 (2%) | 2/55 (4%) | 0/73 (0%) |
| Intra-abdominal pressure | 4/271 (2%) | 3/216 (1%) | 1/55 (2%) | 0/73 (0%) |
| Stress index | 3/271 (1%) | 3/216 (1%) | 0/55 (0%) | 0/73 (0%) |
| Oxygen delivery | 2/271 (1%) | 2/216 (0.9%) | 0/55 (0%) | 0/73 (0%) |
| Airway opening pressure | 1/271 (0.4%) | 1/216 (0.5%) | 0/55 (0%) | 0/73 (0%) |
| Airway occlusion pressure | 1/271 (0.4%) | 1/216 (0.5%) | 0/55 (0%) | 0/73 (0%) |
| NAVA | 1/271 (0.4%) | 1/216 (0.5%) | 0/55 (0%) | 0/73 (0%) |
| R/I ratio | 1/271 (0.4%) | 1/216 (0.5%) | 0/55 (0%) | 0/73 (0%) |
| Time constant | 1/271 (0.4%) | 1/216 (0.5%) | 0/55 (0%) | 0/73 (0%) |
| Weight | 1/271 (0.4%) | 1/216 (0.5%) | 0/55 (0%) | 0/73 (0%) |
Studies that published assessing different methods of determining optimal positive end-expiratory pressure are stratified by overall, study setting, and number of RCTs for each method
*Sum of columns is greater than total as some articles fit more than one category
†Percentages are for total studies within given column
EELV = end-expiratory lung volume; FRC = functional residual capacity; ICU = intensive care unit; NAVA = neurally adjusted ventilatory assist; OR = operating room; PEEP = positive end-expiratory pressure; RCT = randomized controlled trial; R/I = recruitment to inflation