FIGURE 3.

Model‐based exposure and left ventricular ejection fraction analysis. Proportion of patients with LVEF events stratified by osimertinib AUC_ss quartiles (A) and the predicted probability of LVEF events for different osimertinib doses and comparison to observed data (B). Observed data were not plotted for 40 mg and 160 mg due to limited sample size (N = 4 and N = 21, respectively). Vertical bars represent 95% CI. AUC_ss, area under the curve at steady state; CI, confidence interval; EGFR‐TKI, epidermal growth factor receptor‐tyrosine kinase inhibitor; LVEF, left ventricular ejection fraction.