TABLE 1.
Assessment of osimertinib dependency of ILD events using penalized logistic regression.
Model | Intercept (95% CI) | Exposure (95% CI) | Japanese (95% CI) | Asian (non‐Japanese) (95% CI) | Change in OBJ |
---|---|---|---|---|---|
1 | −10.3 (−14.5, −5.93) | 0.741 (0.288, 1.18) | – | – | −10.1 |
2 | −9.83 (−14.3, −5.29) | 0.649 (0.172, 1.11) | 1.42 (0.85, 1.99) | – | −32.7 |
3 | −9.35 (−13.8, −4.76) | 0.628 (0.149, 1.09) | 1.14 (0.510, 1.80) | −0.567 (−1.38, 0.206) | −34.3 |
4 | −3.71 (−4.12, −3.35) | – | 1.51 (0.949, 2.08) | – | −25.8 |
Note: Dashes denote variables that were not included in respective models.
Abbreviations: CI, confidence interval; ILD, interstitial lung disease; OBJ, objective function value.