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. 2024 Nov 27;15:10304. doi: 10.1038/s41467-024-53745-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a The design of mspSA affinity-capture of biotinylated HIV CA Di-hexamer. b Representative 2D classes of HIV-1 CA Di-hexamer generated from 1000 micrographs of mspSA affinity grid and holy carbon grid respectively applied same parameters for blob particle picking. 2D classes are separated into top/bottom- and tilted-views with indicated counts of each group. c Side views related to a 90° rotation of the cryoEM map of the HIV CA Di-hexamer at 3.14 Å resolution overlapped with the atomic models of subunits (colored). d Structural details of peripheral region of helix (aa: 48–81) in close-up views related to a 180° rotation. e The design of mspSA affinity-capture of biotin-tagged DNA/RNA in complex with scPol II. f Representative 2D classes of scPol II EC generated from 1500 micrographs of mspSA affinity grid and holy carbon grid respectively applied same parameters for blob particle picking. 2D classes are separated into dominant- and tilted-views with indicated counts of each group. g Side views related to a 90° rotation of the cryoEM map of the scPol II EC at 2.98 Å resolution overlapped with the atomic models of subunits (colored). h Structural details of peripheral regions of DNA/RNA and helix-loop conjunction aa: (1191–1218) in close-up views.