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. 2024 Nov 28;14:29542. doi: 10.1038/s41598-024-80758-8

Table 4.

The association between SNPs and LDH stratified by severity of lumbar disc herniation and hernia levels.

SNP ID Model Genotype Disc herniation Disc prolapse Single hernia Multiple hernias
OR (95%CI) p p (FDR) OR (95%CI) p p (FDR) OR (95%CI) p p (FDR) OR (95%CI) p p (FDR)
rs1582417 allele G 1 1 1 1
A 1.04 (0.77–1.41) 0.779 0.779 0.96 (0.79–1.17) 0.678 0.678 1.05 (0.82–1.35) 0.677 0.677 0.94 (0.76–1.18) 0.605 0.726
codominant G/G 1 1 1 1
G/A 0.97 (0.62–1.52) 0.886 0.886 0.88 (0.65–1.18) 0.394 0.394 0.85 (0.58–1.24) 0.385 0.577 0.98 (0.71–1.36) 0.916 0.916
A/A 1.17 (0.62–2.20) 0.626 0.939 0.97 (0.64–1.47) 0.888 0.888 1.26 (0.75–2.10) 0.383 0.460 0.85 (0.52–1.40) 0.531 0.637
dominant G/G 1 1 1 1
G/A-A/A 1.01 (0.66–1.55) 0.962 0.962 0.90 (0.69–1.18) 0.455 0.455 0.93 (0.65–1.33) 0.698 0.837 0.95 (0.70–1.31) 0.771 0.771
recessive G/G-G/A 1 1 1 1
A/A 1.19 (0.67–2.13) 0.551 0.827 1.04 (0.71–1.53) 0.841 1.009 1.38 (0.86–2.20) 0.181 0.542 0.86 (0.54–1.37) 0.527 0.632
log-additive – 1.05 (0.78–1.43) 0.735 0.882 0.96 (0.79–1.17) 0.664 0.664 1.06 (0.82–1.36) 0.677 0.677 0.94 (0.75–1.18) 0.596 0.715
rs2431689 allele G 1 1 1 1
A 1.06 (0.71–1.59) 0.769 0.922 1.12 (0.87–1.45) 0.377 0.452 1.35 (0.98–1.85) 0.062 0.123 0.95 (0.70–1.29) 0.744 0.744
codominant G/G 1 1 1 1
G/A 1.04 (0.65–1.67) 0.874 1.048 1.16 (0.86–1.57) 0.324 0.389 1.50 (1.03–2.18) 0.034 0.207 0.89 (0.63–1.28) 0.541 0.649
A/A 1.27 (0.34–4.67) 0.720 0.864 1.09 (0.45–2.68) 0.845 1.014 1.19 (0.37–3.85) 0.771 0.771 1.17 (0.44–3.08) 0.751 0.751
dominant G/G 1 1 1 1
G/A-A/A 1.06 (0.67–1.67) 0.811 0.973 1.16 (0.86–1.55) 0.326 0.391 1.48 (1.02–2.13) 0.038 0.113 0.92 (0.65–1.29) 0.623 0.747
recessive G/G-G/A 1 1 1 1
A/A 1.26 (0.34–4.60) 0.730 0.876 1.05 (0.43–2.56) 0.917 0.917 1.05 (0.33–3.39) 0.929 0.929 1.20 (0.46–3.15) 0.708 0.708
log-additive – 1.07 (0.71–1.59) 0.754 0.754 1.13 (0.87–1.46) 0.366 0.439 1.37 (0.99–1.89) 0.059 0.119 0.95 (0.70–1.29) 0.750 0.750
rs7727115 allele G 1 1 1 1
T 0.80 (0.58–1.11) 0.184 1.102 0.79 (0.64–0.97) 0.022 0.044 0.75 (0.57–0.99) 0.039 0.117 0.78 (0.61–0.98) 0.036 0.071
codominant G/G 1 1 1 1
G/T 0.80 (0.52–1.23) 0.308 0.923 0.80 (0.60–1.05) 0.108 0.216 0.75 (0.52–1.08) 0.122 0.244 0.80 (0.58–1.10) 0.162 0.323
T/T 0.63 (0.28–1.40) 0.254 0.762 0.59 (0.35–0.98) 0.042 0.126 0.56 (0.28–1.12) 0.101 0.302 0.54 (0.29–0.98) 0.043 0.130
dominant G/G 1 1 1 1
G/T-T/T 0.77 (0.51–1.16) 0.210 0.632 0.76 (0.58–0.99) 0.042 0.085 0.72 (0.51–1.02) 0.061 0.122 0.75 (0.55–1.02) 0.064 0.128
recessive G/G-G/T 1 1 1 1
T/T 0.70 (0.32–1.52) 0.365 1.095 0.66 (0.40–1.08) 0.094 0.282 0.64 (0.32–1.26) 0.193 0.290 0.60 (0.33–1.07) 0.085 0.510
log-additive – 0.79 (0.57–1.10) 0.170 1.020 0.78 (0.63–0.96) 0.020 0.041 0.75 (0.57–0.99) 0.042 0.127 0.76 (0.60–0.97) 0.028 0.083
rs17057846 allele G 1 1 1 1
A 1.19 (0.83–1.70) 0.340 0.509 1.18 (0.94–1.49) 0.159 0.239 1.09 (0.80–1.47) 0.584 0.700 1.25 (0.96–1.62) 0.099 0.149
codominant G/G 1 1 1 1
G/A 1.25 (0.81–1.93) 0.320 0.640 1.17 (0.88–1.56) 0.280 0.420 1.02 (0.70–1.48) 0.923 0.923 1.29 (0.93–1.78) 0.122 0.365
A/A 1.20 (0.39–3.72) 0.751 0.751 1.47 (0.73–2.97) 0.284 0.426 1.50 (0.62–3.62) 0.369 0.554 1.48 (0.67–3.29) 0.331 0.496
dominant G/G 1 1 1 1
G/A-A/A 1.24 (0.81–1.90) 0.314 0.627 1.20 (0.91–1.58) 0.199 0.298 1.06 (0.74–1.52) 0.745 0.745 1.31 (0.96–1.79) 0.091 0.137
recessive G/G-G/A 1 1 1 1
A/A 1.11 (0.36–3.40) 0.855 0.855 1.39 (0.69–2.79) 0.352 0.704 1.49 (0.62–3.57) 0.372 0.446 1.36 (0.62–2.98) 0.447 0.671
log-additive – 1.19 (0.83–1.71) 0.350 0.700 1.19 (0.94–1.05) 0.157 0.235 1.10 (0.80–1.49) 0.563 0.676 1.26 (0.97–1.65) 0.088 0.132
rs2961920 allele C 1 1 1 1
A 1.20 (0.89–1.61) 0.230 0.689 1.36 (1.12–1.64) 0.002 0.010 1.44 (1.13–1.83) 0.004 0.022 1.27 (1.02–1.57) 0.033 0.099
codominant C/C 1 1 1 1
C/A 1.31 (0.82–2.10) 0.263 1.580 1.32 (0.97–1.79) 0.075 0.226 1.49 (0.99–2.25) 0.054 0.163 1.28 (0.91–1.81) 0.161 0.323
A/A 1.40 (0.76–2.59) 0.286 0.571 1.86 (1.26–2.74) 0.002 0.010 2.07 (1.25–3.43) 0.005 0.030 1.63 (1.04–2.53) 0.032 0.193
dominant C/C 1 1 1 1
C/A-A/A 1.33 (0.85–2.08) 0.211 0.632 1.45 (1.09–1.94) 0.011 0.033 1.63 (1.11–2.40) 0.013 0.080 1.37 (0.99–1.90) 0.061 0.184
recessive C/C–C/A 1 1 1 1
A/A 1.19 (0.69–2.05) 0.528 1.057 1.58 (1.12–2.21) 0.009 0.053 1.61 (1.05–2.48) 0.031 0.184 1.40 (0.95–2.08) 0.090 0.271
log-additive – 1.20 (0.89–1.62) 0.230 0.689 1.36 (1.12–1.64) 0.002 0.010 1.44 (1.12–1.85) 0.004 0.025 1.03 (1.03–1.59) 0.029 0.057
rs58747524 allele T 1 1 1 1
C 1.18 (0.84–1.65) 0.336 0.673 1.29 (1.04–1.61) 0.019 0.057 1.21 (0.92–1.60) 0.173 0.259 1.36 (1.07–1.73) 0.013 0.079
codominant T/T 1 1 1 1
T/C 0.96 (0.61–1.50) 0.842 1.263 1.41 (1.07–1.86) 0.014 0.087 1.14 (0.79–1.64) 0.480 0.576 1.49 (1.08–2.05) 0.014 0.084
C/C 1.93 (0.87–4.25) 0.104 0.623 1.46 (0.80–2.65) 0.221 0.441 1.70 (0.82–3.49) 0.152 0.303 1.69 (0.87–3.27) 0.119 0.238
dominant T/T 1 1 1 1
T/C–C/C 1.07 (0.70–1.63) 0.756 1.134 1.42 (1.09–1.85) 0.011 0.063 1.20 (0.85–1.71) 0.296 0.445 1.51 (1.11–2.05) 0.008 0.048
recessive T/T-T/C 1 1 1 1
C/C 1.96 (0.91–4.24) 0.087 0.523 1.26 (0.70–2.26) 0.447 0.671 1.61 (0.79–3.26) 0.187 0.374 1.42 (0.75–2.71) 0.283 0.567
log-additive – 1.17 (0.84–1.64) 0.357 0.535 1.32 (1.05–1.65) 0.016 0.047 1.22 (0.92–1.62) 0.172 0.259 1.40 (1.09–1.79) 0.009 0.057

SNP: Single nucleotide polymorphism; OR: Odds ratio; 95% CI: 95% confidence interval; FDR: False discovery rate.

p < 0.05 indicates SNP with statistical significance. The highlighted in bold represent significant association.