Fig. 7. Proposed model for ribosome biogenesis regulation by DDX10 in mESCs.

A schematic working model illustrating the mechanism of DDX10 in regulating ribosome biogenesis. In the presence of DDX10, it functions as a component of the SSU processome within the nucleolus, facilitating the release of U3 snoRNA from pre-rRNA. This activity ensures the maturation of 18S rRNA and the biogenesis of the 40S subunits. In contrast, in the absence of DDX10, the release of U3 snoRNA from pre-rRNA is impaired, resulting in compromised maturation of 18S rRNA and impaired biogenesis of the 40S subunits.