Table 3.
CGM-Derived Primary Endpoints.
| Analysis period | ||||||
|---|---|---|---|---|---|---|
| Period 1 | Period 2 | |||||
| Total number of studies with glycemic PE | 90 | 109 | ||||
| CGM-derived PE | N | M % (SD) | N | M % (SD) | t stat a | P-value a |
| TIR | 7 | 7.9 (6.8) | 29 | 25.6 (13.9) | 2.55 | .038 |
| MAGE | 22 | 23.4 (11.6) | 7 | 6.7 (6.2) | –2.84 | .022 |
| TBR | – | – | 4 | 3.5 (2.6) | 3.00 | .030 |
| CV | 2 | 2.8 (3.9) | 2 | 4.3 (2.4) | –0.55 | .60 |
| GV | 1 | 1.4 (3.1) | 2 | 2.3 (3.4) | 0.45 | .66 |
| AUCcgm | 2 | 1.3 (2.9) | 2 | 2.3 (3.4) | 0.52 | .61 |
| TAR | – | – | 1 | 0.9 (2.1) | 0.18 | .36 |
| MGcgm | 3 | 2.6 (3.6) | 1 | 0.6 (1.3) | –1.14 | .30 |
| CGMprof | 2 | 2.8 (3.9) | – | – | –1.58 | .17 |
a
Two-tailed t test assuming unequal variances.
Abbreviations (AUCcgm) CGM area under the curve, (CV) coefficient of variation, (CGMprof) CGM profile, (GV) glycemic variability, (MAGE) mean amplitude of glycemic excursions, (MGcgm) mean glucose determine by CGM, (TAR) time above range, (TBR) time below range, (TIR) time in range.