Table 3. Schedule of outcomes and measures.
| Screening/baseline | 3 months | 6 months | 9 months | 12 months | 15 months | 18 months | ||
| Primary outcome and measure | ||||||||
| Relapse of MDD (SCID-5-RV: depression module) | x | x | x | x | x | x | x | |
| Secondary outcomes and measures | ||||||||
| Depressive symptoms (QIDS-SR) | Monthly | |||||||
| Time to relapse (SCID-5-RV: depression module) | x | x | x | x | x | x | x | |
| Time to remission (SCID-5-RV: depression module) | x | x | x | x | x | x | x | |
| Rate of remission (SCID-5-RV: depression module) | x | x | x | x | x | x | x | |
| Time in remission (SCID-5-RV: depression module) | x | x | x | x | x | x | x | |
| Anxiety (GAD-7) | x | x | x | x | ||||
| Vocational status (RUQ) | x | x | x | x | ||||
| Cost-effectiveness (RUQ) | x | x | x | x | ||||
| Therapeutic mechanisms and measures | ||||||||
| Mindfulness skills (FMI) | x | x | x | x | ||||
| Self-compassion (SCS-SF) | x | x | x | x | ||||
| Social support (SPS) | x | x | x | x | ||||
| Rumination (RRS-SF) | x | x | x | x | ||||
| Exploratory outcomes and measures | ||||||||
| Stress (PSS) | x | x | x | x | ||||
| Social anxiety (LSAS) | x | x | x | x | ||||
| Loneliness (UCLA Loneliness Scale) | x | x | x | x | ||||
| Self-efficacy (Self-Efficacy Scale) | x | x | x | x | ||||
| Self-esteem (Rosenberg SES) | x | x | x | x | ||||
| Social and general functioning (SOFAS) | x | x | x | x | ||||
| Suicidal ideation and attempts in past 6 months (CSSRS) | x | x | x | x | ||||
| Deliberate self-harm (Risk Taking and Self-Harm Inventory†) | x | x | x | x | ||||
| Psychological well-being (BPNSS) | x | x | x | x | ||||
| Quality of life (AQoL-8D) | x | x | x | x | ||||
| Behavioural activation (BADS-SF) | x | x | x | x | ||||
| Sleep quality (PSQI) | x | x | x | x | ||||
| Strengths use (SUS) | x | x | x | x | ||||
| Medication adherence (RUQ)* | x | x | x | x | ||||
| Substance use (ASSIST)* | x | x | x | x | ||||
| Digital phenotype (AWARE-Light) | Continuous | |||||||
| Affective and cognitive reactivity and social support (SEMA3 application) | Daily | |||||||
| Intervention group-only outcomes and measures | ||||||||
| Intervention acceptability (qualitative evaluation via semistructured interview) | x | |||||||
| Therapeutic alliance (WAI-C, WAI-T) | x | x | x | x | ||||
| Intervention use (ie, frequency, duration, pattern) | Continuous | |||||||
Potential covariates.
Risk Taking and Self-Harm Inventory for Adolescents.
AQoL-8DAssessment of Quality of Life - 8 DimensionsASSISTAlcohol, Smoking and Substance Involvement Screening Test BADS-SFBehavioural Activation for Depression Scale-short formBPNSSBasic Psychological Needs Satisfaction ScaleCSSRSColumbia-Suicide Severity Rating ScaleFMIFreiburg Mindfulness InventoryGAD-7Generalized Anxiety Disorder 7-item scaleLSASLiebowitz Social Anxiety ScaleMDDmajor depressive disorderPSQIPittsburgh Sleep Quality IndexPSSPerceived Stress ScaleQIDS-SRQuick Inventory of Depressive Symptomatology-Self-ReportRRS-SFRuminative Responses Scale - short formRUQResource Use QuestionnaireSCID-5-RVStructured Clinical Interview for DSM-5 Disorders, Research VersionSCS-SFSelf-Compassion Scale Short FormSEMA3Smartphone Ecological Momentary AssessmentSESSelf-Esteem ScaleSOFASSocial and Occupational Functioning Assessment ScaleSPSSocial Provisions ScaleSUSStrengths Use ScaleUCLAUCLA Loneliness Scale (Version 3)WAI-CWorking Alliance Inventory client versionWAI-TWorking Alliance Inventory therapist version